A cooperative action between diphenyl diselenide and the ironiii chloride is essential to provide good yields of the cyclized product. Download fulltext pdf effects of diphenyl diselenide on methylmercury toxicity in rats article pdf available in biomed research international 202. In vitro antifungal evaluation and structureactivity. The fish were fed for 60 days with a diet in the absence or in the presence of 3. Pdf diphenyl diselenide derivatives inhibit microbial. Synthesis of polystyrene with carboncarbon double bonds at both chain ends. Diphenyl diselenide manufacturers, producers, cas no 1666. It is used in the synthesis of the unsymmetrical diorganyl selenides, 1phenylselenomethylvinyl selenides, allylic phenyl selenides. The reaction takes place via the pathway outlined in scheme 5. Diphenyl diselenide protects neuronal cells against oxidative stress. This colorless crystalline material is often abbreviated ph 2 s 2. Diphenyl diselenide modulates gene expression of antioxidant enzymes in cerebral cortex, hippocampus and striatum of female hypothyroid rats. Diphenyl diselenide is used as a source of the phse unit in organic synthesis, mumbai, india.
The treatment of nallylacetylhydrazides 120 with diphenyl diselenide at. Ebs showed in vitro activity against t asahii strains with minimal inhibitory concentration mic. Diphenyl diselenide and analogs are substrates of cerebral. Diphenyl diselenide, phse2, is an organoselenium compound that affects a number of neuronal processes. Antifungal activity of diphenyl diselenide alone and in. In this study, we evaluated the antifungal activities of fluconazole, amphotericin b and flucytosine, in combination with diphenyl diselenide against 30 clinical isolates of cryptococcus spp.
It is hazardous substance use as general industrial fine chemical. This study evaluated the in vitro susceptibility of trichosporon asahii strains to diphenyl diselenide dpds and ebselen ebs alone and in combination with amphotericin b amb, fluconazole fcz, itraconazole itz and caspofungin cas using the microdilution method. The benefits of exercise and the element selenium on mental health and cognitive performance are well documented. Several in vivo experiments show that phse 2 reduces the levels of proinflammatory cytokines and reactive species in various pathologies. Male wistar rats 24 months were fed daily with standard diet chow.
Diphenyl diselenide phse2 312 9 2,2diselenidyldibenzoic acid dsba 402 10 camphor diselenide 332 11 2,2diselenidyldinicotinicic acid 404 10 c bisethyl n2selenobenzoylglycinate 570 10 d bis2selenon1methyl2phenylethylbenzamide 634 10 e sancineto et al. Antiinflammatory and antinociceptive activity of diphenyl diselenide. Diphenyl diselenide was able to increase npsh levels in erythrocytes of rabbits 42 and in different tissues of mice. Diphenyl diselenide, one of the more promising organoselenium compounds, was assessed in two studies by either oral or subcutaneous route with favorable resultsthe substance significantly inhibited pain behavior in the formalin, capsaicin, glutamate, bradykinin, and writhing test savegnago et al.
In addition, the figure 2 legend and table 1 note are incomplete. A convenient synthesis of phenylselenocarbonyl compounds. Here we show for the first time that diselenides are good substrates for mammalian trxr, but not necessarily good mimetics of gpx, and vice. Find patient medical information for diphenyl oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The clp regulation makes sure that the hazards presented by chemicals are. Diphenyl diselenide is the chemical compound with the formula c6h52se2, abbreviated. Over the past years, organoselenium compounds have been aimed as targets of interest in organic synthesis. Indiumi iodide promoted cleavage of diphenyl diselenide. Diphenyl diselenide and diphenyl ditelluride increase the latency for 4aminopyridineinduced chemical seizure and prevent death in mice. Diphenyl diselenide modulates nucleotidases, reducing. Binary systems consisting of benzoyl peroxide bpo and diorganyl diselenide are effective in the selective benzoyloxyselenation of internal alkynes to afford the corresponding. The purpose of the present study was to investigate whether the intake of a diet supplemented with diphenyl diselenide phse 2 and the swimming exercise could enhance memory in old wistar rats.
In view of the concerns with the use of mammals in studies and the great number of new organochalcogens with potential pharmacological. This selective sequential addition and cyclization is facilitated by the rate of carbon. Carrageenininduced paw edema, tailflick, formalin, acetic acidinduced abdominal writhing and. Diphenyl diselenide an overview sciencedirect topics. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is. In vitro activity of diphenyl diselenide and ebselen alone. Sigmaaldrich offers a number of diphenyl diselenide products. Diphenyl diselenide also produced dosedependent antinociception when assessed in acetic acidinduced abdominal. Three hours after phse 2 administration, the animals were sacrificed and. Protective effects of diphenyl diselenide in a mouse model of. Diphenyl diselenide phse 2 is an organoselenium compound with antioxidant, antiviral, and immunomodulatory activities. Pdf molecular effects of diphenyl diselenide on cholesterol. The ironiii coordination with one selenium atom from the diselenide activates the other selenium toward nucleophilic attack by the alkyne to give the seleniranium ion xxi. In contrast, ebselen and bistrifluoromethyldiphenyl diselenide, that have been previously demonstrated to be.
On the other hand, diphenyl diselenide was more efficient and gave satisfactory transformation of the starting alkynes into 1,2. Pdf reduction of diphenyl diselenide and analogs by. Adult male wistar rats and albino mice were treated with diaryl diselenides and ebselen in different doses. Hazardous in case of eye contact irritant, of ingestion, of. Organometallics are useful reagent, catalyst, and precursor materials with applications in thin film deposition, industrial chemistry, pharmaceuticals, led manufacturing, and others. Humans are ubiquitously exposed to bisphenol a bpa, one of the most used synthetic monomers for manufacturing polycarbonate plastics. This set index page lists chemical compounds articles associated with the same name. We operate in more than 30 countries and deliver an extensive portfolio of mission critical products, services and solutions. Since diphenyl diselenide action on low molecular endogenous thiol depends on a variety of factors including species, this organoselenium compound was investigated in different species. An electrophilic selenenylating agent of double bonds. Body weight gain and motor deficits were evaluated prior to treatment, on treatment days 11 and.
Avantor is a trusted global partner to customers and suppliers in the life science, advanced technology and applied materials industries. Please note that we cannot offer bulk quantities for some. As macrophages respond to microenvironmental stimu. Pharmacology and toxicology of diphenyl diselenide in several. Manufacturers, suppliers and producers of diphenyl diselenide cas no 16663 is the chemical compound with the formula c6h52se2, abbreviated ph2se2 this orangecoloured solid is the oxidized derivative of benzeneselenol. In this study, the protective effects of diphenyl diselenide phse 2 on quinclorac induced toxicity were investigated in silver catfish rhamdia quelen. Diphenyl diselenide 98% phenyl diselenide sigmaaldrich. Diphenyl disulfide is the chemical compound with the formula c 6 h 5 s 2. In this study, the authors evaluated the ability of diphenyl diselenide phse 2 to reverse acute hepatic failure induced by acetaminophen apap in mice. Adult rats were treated with mehg 5 mgkgday, intragastrically i. The tile of the paper should be changed to address the differential genotoxicity of diphenyl diselenide phse2 and diphenyl ditelluride phte2, rather than protective effects of diphenyl diselenide phse2, as no toxicants are used for phse2 to protect against.
Review history for differential genotoxicity of diphenyl. Selenium rarely occurs in its elemental state in nature and is usually found in sulfide ores such as pyrite, partially replacing the sulfur in the ore matrix. Diphenyl diselenide mimicking gpx and also is substrate of rat brain trxr. Diphenyl diselenide derivatives inhibit microbial biofilm formation involved in wound infection. This study was designed to investigate the molecular effects of diphenyl diselenide. Download fulltext pdf download fulltext pdf differential genotoxicity of diphenyl diselenide phse2 and diphenyl ditelluride phte2 article pdf available in peerj 21. The structure of the vicinal dicarbonyl compounds were confirmed by applying a subsequent condensation reaction to construct the corresponding quinoxaline derivatives. Differential genotoxicity of diphenyl diselenide phse2. Interestingly, diphenyl diselenide shares several antioxidant and neuroprotective properties with ebselen. A benzoyl peroxidediphenyl diselenide binary system for.
In fact, there is a dearth of information on the ability of other organoselenium compounds, especially diphenyl diselenide and its analogs, to serve as substrates for the mammalian enzyme thioredoxin reductase. Diphenyl diselenide 16663 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals. Phse 2 and phte 2 are the simplest of the diaryl dichalcogenides and share with ebselen pharmacological properties. Diphenyl diselenide and analogs are substrates of cerebral rat. Sporothrix brasiliensis is the main agent of feline and zoonotic sporotrichosis. General description diphenyl ditelluride phte 2 is a versatile reagent used in the organic synthesis. Pdf differential genotoxicity of diphenyl diselenide phse. Pdf effects of diphenyl diselenide on methylmercury. Diphenyl diselenide modulates oxldlinduced cytotoxicity. In the present work, we investigated the mechanisms underlying the protective effect exerted by phse2 on oxldlmediated effects in murine j774 macrophagelike cells. Efficacy of diphenyl diselenide against cerebral and. Living radical polymerization of styrene with diphenyl. It is one of the more commonly encountered organic disulfides in organic synthesis. Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidaselike activity.
Redoxmodulating and antiproliferative properties article pdf available in oxidative medicine and cellular longevity 20191. Organochalcogens, particularly ebselen, have been used in experimental and clinical trials with borderline efficacy. Diphenyl diselenide phse2, a simple organoselenium compound, possesses interesting pharmacological properties that are under extensive research. Summary this study evaluated the in vitro susceptibility of trichosporon asahii strains to diphenyl diselenide dpds and ebselen ebs alone and in combination with amphotericin b amb, fluconazo. Cdata reaction of diphenyl diselenide with hydrogen peroxide and inhibition of deltaaminolevulinate dehydratase from rat liver and cucumber leaves. A simple and convenient procedure has been developed for the synthesis of phenylselenocarbonyl compounds by a one. Diphenyl diselenidemodulation of macrophage activation. In contrast to internal alkynes, terminal alkynes undergo a novel csph substitution with the phenylseleno group of the bpophse2 system, providing alkynyl. This study investigates the efficacy of diphenyl diselenide phse 2 in attenuating methylmercury mehginduced toxicity in rats. Comparative toxicological effects of diphenyl diselenide and phte 2 in mice after in vivo administration has been reported. Differential genotoxicity of diphenyl diselenide phse2 and. Structure, properties, spectra, suppliers and links for. The hazard classification and labelling section shows the hazards of a substance based on the standardised system of statements and pictograms established under the clp classification labelling and packaging regulation. In vitro combination between antifungals and diphenyl.
Elemental iodine or diphenyl diselenide in the bis. Diphenyl diselenide derivatives inhibit microbial biofilm formation. Its standard enthalpies of combustion, formation and the mean bonddissociation energy have been calculated. Diphenyl diselenide in its selenol form has dehydroascorbate reductase and glutathione stransferaselike activity dependent on the glutathione content. At room temperature, the initially formed 1,3,4oxadiazines 122 are converted completely to. Downregulation of classical and alternative activation markers luc. Neurotoxicity by phte 2 depends on the modulation of signaling pathways initiated at the plasma membrane. Sarex provide diphenyl diselenide with cas no 16663.
Diphenyl diselenide protects neuronal cells against oxidative. Pdf diphenyl diselenide has shown interesting biological activities in various freeradicalinduced damage models and can be. Minor contamination by thiophenol is responsible for the disagreeable odour associated with this compound. Diphenyl diselenide abrogates brain oxidative injury and.
Its crystalline structure, toxicokinetic properties, antioxidant and antiinflammatory activities have been investigated. Search results for diphenyl diselenide at sigmaaldrich. Diphenyl diselenide protects neuronal cells against. Diphenyl diselenide abrogates brain oxidative injury and neurobehavioural deficits associated. A convenient synthesis of phenylselenocarbonyl compounds by. Given the scarcity of options for sporotrichosis treatment and the promising activity of diphenyl diselenide phse 2 against a diversity of fungal pathogens, this study aimed to evaluate the in vitro susceptibility of sporothrix brasiliensis to phse 2 alone and in. Manganese diselenide mnse 2 molybdenum diselenide mose 2 tungsten diselenide wse 2 titanium diselenide tise 2. The animals received an apap dose of 600 mgkg intraperitoneally i. In contrast, the potential therapeutic aspects of tellurides have not yet been demonstrated. Diphenyl diselenide modulates oxldlinduced cytotoxicity in. Its ability to reverse the oxidative brain damage and mitochondrial dysfunction induced by acetaminophen has been studied in mice.
Diphenyl diselenide, c 6 h 5sesec 6 h 5 metal dichalcogenides. Females are more susceptible than male mice to thermal. Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction. In the present study, the antiinflammatory and antinociceptive activity of diaryl diselenides and ebselen was studied. Diphenyl diselenide protects against methylmercury. Diphenyl diselenide derivatives inhibit microbial biofilm. Given the scarcity of options for sporotrichosis treatment and the promising activity of diphenyl diselenide phse 2 against a diversity of fungal pathogens, this study aimed to evaluate the in vitro susceptibility of sporothrix brasiliensis to phse 2 alone and in combination with itraconazole itc. Sep 28, 2007 efficacy of diphenyl diselenide against cerebral and pulmonary damage induced by cadmium in mice. Antiinflammatory and antinociceptive activity of diphenyl. Diphenyl diselenide is a chemically synthesised molecule with was found to have antimicrobial activity. Living radical polymerization of styrene with diphenyl diselenide as a photoiniferter. Pdf interaction profile of diphenyl diselenide with.
Reduction of acute hepatic damage induced by acetaminophen. Diphenyl diselenide is one of numerous organometallic compounds sold by american elements under the trade name ae organometallics. Pdf pharmacology and toxicology of diphenyl diselenide in. Diet with diphenyl diselenide mitigates quinclorac. Items available from stock in japan will be delivered in 12 weeks. The present study evaluated the comparative toxicological effects of diphenyl diselenide phse2 and diphenyl ditelluride phte2 in mice after in vivo administration. In vitro antifungal evaluation and structureactivity relationship of diphenyl diselenide and synthetic analogues.
Highly selective sequential addition and cyclization. Pdf diphenyl diselenide changes behavior in female pups. Hazard identification potential acute health effects. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided. Pdf diphenyl diselenide modulates gene expression of. In effect, the reduction of ebselen or its diselenide and of diphenyl diselenide by brain trxr can be an important molecular mechanism involved in their neuroprotective properties. Effects of diphenyl diselenide on methylmercury toxicity in rats. Diphenyl diselenide is used in the methoxyselenenylation of alkenes, dihydroxylation of double bonds, hydrothiolation of terminal alkynes. This orangecoloured solid is the oxidized derivative of benzeneselenol. Pdf differential genotoxicity of diphenyl diselenide. Molecular effects of diphenyl diselenide on cholesterol and glucose cell metabolism. Animals were further exposed to 1 mgl quinclorac for 8 days. Diphenyl diselenide is a chemical compound of selenium. It is used as a source of the phse unit in organic synthesis.
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